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Academic Publication of the Team Led by Professor Xiancang Ma was Published on Schizophrenia Bulletin

Updated: Apr 27, 2020
From: ​ Department of Psychiatry
Edited by: Liu Huiting
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Days ago, “Assessing the Causal Effects of Human Serum Metabolites on 5 Major Psychiatric Disorders”, the major academic publication of the team led by Professor Xiancang Ma, was published online as an “Article” on the TOP journalSchizophrenia Bulletinin the field of psychiatry. This journal, listed in Area 1 of JCR with the impact factor of 7.289 in 2018, ranks the sixth in 146 professional journals of psychiatry and the first in the field of schizophrenia. The sole author unit is The First Affiliated Hospital of Xi'an Jiaotong University, Research Associate Jian Yang at the Clinical Research Center is the first author, and Professor Xiancang Ma is the corresponding author.

In recent years, the development of genomics, proteomics and metabonomics has provided a new thinking of revealing the pathogenesis of complex diseases from the perspective of systems biology. Psychiatric disorders are complex diseases closely correlated to genetics and metabolism. So far, the genome-wide correlation studies (GWASs) correlated to psychiatric disorders and those on metabonomics have made great achievements, but no studies have been carried out to integrate the genomics with metabonomics, and explore the role of the interaction between genetics and metabolism in the pathogenesis of psychiatric disorders. In this study, Mendelian randomization was adopted to extract the related genetic loci from the study data of the largest metabolic phenotype GWAS, and infer the causal correlation between metabolomic phenotype and psychiatric disorders with genetic loci as the variants.

In this study, more than 100 metabolites were found to be correlated to psychiatric disorders, for example, 2-methoxyacetaminophen has a significant negative correlation with schizophrenia, and 1-docosahexaenoic acyl glycerol phosphocholin has a positive correlation with ADHD. At the same time, through further analysis on metabolic pathways, several metabolic pathways correlated to psychiatric disorders were identified in this study. This study also located the genetic loci determining the correlation between metabolites and psychiatric disorders, thus providing several potential targets for the diagnosis and treatment of schizophrenia.

Links:https://academic.oup.com/schizophreniabulletin/advance-article/doi/10.1093/schbul/sbz138/5699662#

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