NTRK-rearranged spindle cell tumor is a rare soft tissue tumor with NTRK gene rearrangement as molecular features. It is a group of soft tissue tumors defined by molecular genetic characteristics, which predominantly occur in children and adolescents, occasionally in adults. Most of them are located in the superficial or deep soft tissues of human limbs and trunk, and occasionally involves with abdominal organs. However, it is previously thought that this tumor never invades into the brain.

This rare case in our hospital is the second case worldwide, and the first case of NTRK-rearranged spindle cell intracranial tumor in China. The diagnosis of this case is a typical reflection of clinical-scientific research translation in our hospital. Professor Wang Tuo from Department of Neurosurgery delivered MDT consultation with Professor Gong Huilin from Department of Pathology, Professor Zhao Dongli from Department of Radiation Oncology, doctoral students Ma Shaohui and Bian Yitong from Department of Radiology, then confirmed the diagnosis and finally published relevant results in a prestigious pathology journal.

Professor Wang Tuo's MDT team consists of oncology group of Department of Neurosurgery, Department of Pathology, Department of Radiology, Department of Radiation Oncology, Gamma-knife Treatment Center and other neuro-oncology departments. Currently, it is the only neuro-oncology MDT team running normally in northwest China, bringing clinical benefits to hundreds of patients. With MDT discussion of complex intracranial tumors as a tool and providing precision treatment of complex nervous system tumors as the goal, the MDT team maintains academic exchanges with Tiantan Hospital, Xuanwu Hospital and West China Hospital on a regular basis. Professor Wang Tuo will be committed to leading the MDT team of complex intracranial tumors to adhere to the concept, further explore minimally invasive treatment and MDT diagnosis and treatment strategies for complex intracranial tumors, and serve the patients.