On the afternoon of July 1, 2022, the third lecture of【IN TALK】China-Singapore Dialogue-Special Session for Top-notched CNS Lecturers was held online. Professor Wang Xiaomeng, a tenured Associate Professor at Duke-National University of Singapore Graduate Medical School and Director of Singapore Eye Research Institute (SERI), was invited to deliver a lecture. Professor She Junjun, Assistant-to-President of the First Affiliated Hospital of Xi'an Jiaotong University (XJTU), Professor Guo Hui, Deputy Director of Department of Science and Technology, Associate Research Fellow Tu Kangsheng, Deputy Director of Clinical Research Center, Associate Research Fellow Yang Qi, Deputy Director of Department of Otolaryngology, Associate Research FellowQu Kai, Deputy Director of Biobank, and Associate Research Fellow Wang Jichang from Department of Vascular Surgery attended this lecture, which was chaired by Ren Hui, Deputy Director of International Exchange Office.

First, Ren Hui introduced the background significance, keynote speakers and guests of the series activities of【IN TALK】. She highlighted that this video connection with Professor Wang Xiaomeng is a continuation of substantial cooperation between bilateral sides since the last visit of Professor Wang Xiaomeng to our hospital, hoping to learn advanced scientific research experience through this online connection. Subsequently, Professor Wang Xiaomeng gave a keynote speech entitledTranslational research in fibrovascular complicationsand systematically introduced her team’s outstanding research achievements in the previous decade. In 2013, Professor Wang Xiaomeng published an article entitled LRG1 promotes angiogenesis by modulating endothelial TGF-β signaling in Nature and systematically illustrated the role of LRG1 in human body for the first time. As the "regulatory rod" of endothelial TGF-β signaling pathway, LRG1 can be switched to promote angiogenesis. Then, Professor Wang Xiaomeng's team found that LRG1 played a pivotal role in more than 10 types of diseases, such as cardiac fibrosis, metabolic diseases, cancer and immune diseases,etc.Understanding the role of LRG1, as a mediator of TGF-β signaling pathway, in various diseases is crucial for drug research and development based on the TGF-β signaling pathway.

After the lecture, all guests had in-depth discussion with Professor Wang Xiaomeng regarding their respective research fields. Experts hoped to take this lecture as an opportunity to strengthen in-depth international exchange and cooperation in scientific research from different models and disease spectrums.

Finally, Ren Hui gave a concluding speech, hoping that scientific researchpractioners can actively contact with prestigious experts in related fields at home and abroad,implement in-depth integration of clinical and basic sciences, carry out multidisciplinary combination of medical and science and technology disciplines by taking respective advantages and create significant scientific research findings in relevant fields.