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Our hospital obtains another Major Scientific Research Equipment Development Project of National Natural Science Foundation of China

Updated: Nov 22, 2021
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Edited by: Liu Huiting
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Recently, Professor Han Suxia from Department of Radiation Oncology of the First Affiliated Hospital of Xi’an Jiaotong University (XJTU) received the financial support of Major Scientific Research Equipment Development Project of National Natural Science Foundation of China with the project entitled "Development of real-time monitoring and evaluation system for precise radiotherapy of tumors based on CLI multimodal functional imaging", with a direct funding of 9,085,400 yuan. This is the second time since Professor Lyu Yi obtained Major Scientific Research Equipment Development Project in 2017.

http://www.dyyy.xjtu.edu.cn/__local/F/63/93/8E7DDDED49F3B07E271C9B76A82_FD849063_1CA2C.png

Considering the problems that additional irradiation dose should be introduced in current monitoring and evaluation system for precise radiotherapy or the failure of delivering accurate monitoring in a real-time pattern, a new model of real-time monitoring and evaluation system for precise radiotherapy of tumors based on Cherenkov Luminescence Imaging (CLI) technology was established in this project. This project focused on the development of integrated synchronous 3D radiation monitoring subsystem and multi-modal image data analysis and central control subsystem: ring-shaped integrated structure was designed, range-gated gate-control technology and single photon counting mode algorithm were adopted to improve the signal-to-noise ratio and realize high-precision and high-stability synchronous imaging of extremely weak Cherenkov light. Optical technology and related algorithms were developed to obtain 3D dose and position information corresponding to the target area. The dose and position deviations of the radiotherapy target area were calculated through multi-modal image fusion and registration, and real-time feedback could be provided. Original biomedical mathematical and physical model library was established. Biomedical spectral distribution of the target area was acquired to analyze the temporal and spatial changes of tumor oxygen environment. The relationship between tumor-related genes and radiosensitivity was investigated to identify the radiosensitization targets. In this project, a novel platform for radiation physics and biological research will be built, providing a novel tool for scientific research of precise radiotherapy.

Since 2018, Professor Han Suxia has proposed the problems encountered in tumor precise radiotherapy according to clinical needs, and set up an interdisciplinary team consisting of physicians and engineers to resolve these problems by developing new scientific equipment. Professor Han Suxia led doctoral students Xie Lina, Gao Chengyi and other students to deliver multi-round discussion of this project with the cooperation team, and paid a visit toShandong Shinva Medical Co., Ltd. to determine the research plan and repeatedly revise the bidding documents. Through unremitting efforts, this project was successfully approved this year.

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