Recently, “P300 Acetyltransferase Mediates Stiffness-Induced Activation of Hepatic Stellate Cells Into Tumor-promoting Myofibroblasts”, a research work of Dr. Dou Changwei, Dr. Liu Zhikui and Associate Researcher Tu Kangsheng of Professor Liu Qingguang’s team from Hepatological Surgery Department of our hospital, was published in Gastroenterology (IF=18.392),which was the best journal in gastroenterology and hepatology and the journal of medical zone 1 in SCI and JCR of Chinese Academy of Sciences.
High substrate hardness induced HSC activation and P300 in-core accumulation were innovatively discovered in this research and P300 was found toplay a vital control role in HSC activation of high substrate hardness induction. High substrate hardness, by activating RhoA-Akt signal, could induce P300 phosphorylation (S1834) and then promote P300 in-core accumulation, and P300 could promote the expression of a series of transfer promoters, like CXCL12 through epigenetic modification. This research provided a new molecular mechanism for HSC promoting metastatic tumor growth in liver tumor microenvironment, and also provided a potential therapeutic target for reducing tumor’s plantation and metastatic growth in the liver.
This research was completed under the guidance of Professor Liu Qingguang from Hepatological Surgery Department of theFirst Affiliated Hospital of Xi’an Jiaotong University, Professor Ningling Kang from Hormel Institute of University of Minnesota, and Professor Vijay H. Shah from Mayo Clinic. In recent years, Professor Liu Qingguang has been engaged in the basic-clinical-transformation research and discipline construction of liver tumor microenvironment, focused on the training and cultivation of clinical and scientific thinking of graduate students, adopted the cultivation mode of clinical practice before fundamental research, and obtained many scientific achievements promising in clinical application.
Link address of paper:
http://www.gastrojournal.org/article/S0016-5085(18)30209-9/fulltext
https://www.ncbi.nlm.nih.gov/pubmed/29454793
