General information

July, 1994-August,1996   Physician,   Department of Neurosurgery, the Third Hospital of PLA

July, 1998-September, 2003   Physician and Attending Physician,  Department of Neurosurgery, the Second Affiliated Hospital of Fourth Military Medical University

September, 2003-September, 2009  Associate Professor and Deputy Chief Physician,  Department of Neurosurgery, the Second Affiliated Hospital of Fourth Military Medical University

September, 2009-April, 2019  Professor and Chief Physician,  Department of Neurosurgery, the Second Affiliated Hospital of Fourth Military Medical University

May, 2019-present  Director of Department of Neurosurgery, the First Affiliated Hospital of XJTU

 

Professional memberships

Executive Director China Association Against Epilepsy （2019）

Standing Committee Member  Neurosurgery branch of Chinese Research Hospital Association

Chairman Shaanxi Antiepileptic Association （2021）

Vice Chairman  Neurosurgery branch of Shaanxi Medical Doctor Association

Standing Committee Member  Society of Neurosurgery, Shaanxi Medical Association

Deputy Director  Youth Member Committee of Shaanxi Society of Neurosurgery

 

Academic and scientific achievements

Twenty-six articles have been published by Zhang Hua as the first or corresponding author in SCI-indexed journals:

1. Li Huanfa., Meng Qiang., Liu Yong., Dong Shan., Zhang Hua. Oral and manual automatisms elicited by electrical stimulation of the pars opercularis cortex in a patient with frontal lobe epilepsy. Clin Neurol Neurosurg, 2021.106784（IF1.876）

2. Wu Hao., Liu Yong., Liu Lishuo., Meng Qiang., Du Changwang., Li Kuo., Dong Shan., Zhang Yong., Li Huanfa., Zhang Hua. Decreased expression of the clock gene Bmal1 is involved in the pathogenesis of temporal lobe epilepsy. Mol Brain, 2021; 14(1), 113. （IF4.041）

3. Liu Yong., Meng Qiang., Li Huanfa., Wu Hao., Dong Shan., Zhang Hua. Optimal Surgical Approach for the Dumbbell-Shaped Trigeminal Schwannoma. J Craniofac Surg, 2021.doi:10.1097/SCS.0000000000007701（IF0.953）

4. Wu Hao, Meng Qiang, Zhang Yu, Li Huanfa, Liu Yong, Dong Shan, Liu Bei, Zhang Hua. Upregulated Nmnat2 causes neuronal death and increases seizure susceptibility in temporal lobe epilepsy. Brain Res Bull, 2021;167:1-10. (IF3.37)

5. Wu Hao, Liu Yong, Li Huanfa, Du Changwang, Li Kuo, Dong Shan, Meng Qiang, Zhang Hua. TRAK1-Mediated Abnormality of Mitochondrial Fission Increases Seizure Susceptibility in Temporal Lobe Epilepsy. Mol Neurobiol, 2021;58(3): 1237-1247. (IF4.5)

6. Jin-Tao Liu, Sheng-Xi Wu, Hua Zhang, Fang Kuang. Inhibition of MyD88 Signaling Skews Microglia/Macrophage Polarizationand Attenuates Neuronal Apoptosis in the Hippocampus AfterStatus Epilepticus in Mice. Neurotherapeutics,2018:15:1093–1111(IF5.719)

7. Jin-tao Liu, Bei Liu , Hua Zhang. Surgical versus medical treatment of drug-resistant epilepsy: A systematic review and meta-analysis. Epilepsy & Behavior, 2018:82: 179-188(IF2.6)

8. Zhang H, Gao G, Zhang Y, Sun Y,Li H, Dong S, Ma W, Liu B,Wang W, Wu H, Zhang H. Glucose Defciency Elevates AcidSensing Ion Channel 2a Expressionand Increases Seizure Susceptibilityin Temporal Lobe Epilepsy.Sci Rep. 2017; 7: 5870-5883. (IF4.26)

9. Liu B, Li H,Gao C, Zhang Y, Wang C, Wu H, Dong S, Tao Y, Zhang H. Occurrence predictors of the temporal interictal epileptic dischargesin epilepsy patients with extratemporal lesions: A prospective cohortstudy. INT J SURG,2016:31:52-57.(IF2.21)

10. Tao Y,Chen T,Liu B,Yang GQ,Peng G, Zhang H, Huang YF. The neurotoxic effects of N-methyl-N-nitrosourea on the electrophysiological property and visual signal transmission of rat's retina. Toxicol Appl Pharmacol. 2015;286:44-52. (IF3.63)

11. Wu H, Wang C, Liu B, Li H, Zhang Y, Dong S, Gao G, Zhang H. Altered Expression Pattern of Acid-Sensing Ion Channel Isoforms in Piriform Cortex After Seizures.Mol Neurobiol. 2015;53(3)1782-1793 (IF5.286)

12. Gao C, Wang C, Liu B, Wu H, Yang Q, Jin J, Li H, Dong S, Gao G, Zhang H.Intermittent Hypoxia Preconditioning-Induced Epileptic Tolerance by Upregulation of Monocarboxylate Transporter 4 Expression in Rat Hippocampal Astrocytes.Neurochem Res. 2014; 39:2160–2169(IF.2.551)

13. Liu B, Niu L, Shen MZ, Gao L, Wang C, Li J, Song LJ, Tao Y, Meng Q, Yang QL,Gao GD, Zhang H. Decreased AstroglialMonocarboxylate Transporter 4 Expression in Temporal Lobe Epilepsy. MolNeurobiol. 2014;50:327–338.(IF5.471)

14. Guo H, Zhang H (Co-first author), Kuang Y, Wang C, Jing X, Gu J, Gao G. Electrical Stimulation of the Substantia Nigra Pars Reticulata (SNr) Suppresses Chemically Induced Neocortical Seizures in Rats. J MolNeurosci. 2014；53:546–552.(IF2.891)

15. Yu You, Yaqun Zhao, Hui Bai, Zhiliang Liu, FanxinMeng, Hua Zhang, RuxiangXu: Glatiramer acetate, an anti-demyelination drug, reduced rats’ epileptic seizures induced by pentylenetetrazol via protection of myelin sheath. European Journal of Pharmaceutical Sciences 2013; 49 (3) 366–370(IF2.987)

16. Liu B, Wang L, Shen LL, Shen MZ, Guo XD, Wang T, Liang QC, Wang C, Zheng J, Li Y, Jia LT, Zhang H, Gao GD:RNAi-mediated inhibition of presenilin 2 inhibits glioma cell growth and invasion and is involved in the regulation of Nrg1/ErbB signaling. Neuro Oncol. 2012;14(8):994-1006 (IF6.18)

17. Wang L, Guo H, Yu X, Wang S, Xu C, Fu F, Jing X, Zhang H, Dong X:Responsive electrical stimulation suppresses epileptic seizures in rats. PLoS One. 2012;7(5):e38141（IF:4.092）

18. You Y, Bai H, Wang C, Liu B, Zhang H, Gao GD： Myelin damage of hippocampus and cerebral cortex in rat pentylenetetrazol model. Brain Research 2011; 1381: 208-216 （IF:2.728）

19. Liu B, Wang T, Wang L, Wang C, Zhang H, Gao GD: Up-regulation of major vault protein in the frontal cortex of patients with intractable frontal lobe epilepsy. J Neurol Sci 2011; 308(1-2):88-93.（IF:2.353）

20. Wang L, Wang C, Fu F, Yu X, Guo H, Xu CH, Jing XR, Zhang H, Dong XZ：Temporal lobe seizure prediction based on a complex Gaussian wavelet. Clinical Neurophysiology 2011; 122(4): 656-663（IF:3.406）

21. Liu B,Zhang B, Wang T, Liang QC, Jing XR, Zheng J, Wang C, Meng Q, Wang L, Wang W, Guo H, You Y, Zhang H, Gao GD: Increased expression of urokinase-type plasminogen activator receptor in the frontal cortex of patients with intractable frontal lobe epilepsy. J Neurosci Res 2010; 88(12):2747-54.（IF:2.986）

22. Zhang H, Yao QH, Zhao X，Jing XR, Wang C, Guo H, You Y, Wang HW, Gao GD: A Hypermotor Seizure with a Focal Orbital Frontal Lesion Originating in the Insula. Epilepsy Research 2008; 82: 211-214 (IF2.241)

23. Yao QH, Zhang H (Co-first author), Wang HW, Jing XR, Guo H, Gao GD：Low- and high-frequency electric cortical stimulation suppresses the ferric chloride-induced seizures in rats. Neuroscience Letters 2008; 430(3)：187-90 (IF:2.026)

24. Liang QC, Xiong H, Zhao ZW, Jia D, Li WX, Qin HZ, Deng JP, Gao L, Zhang H, Gao GD： Inhibition of transcription factor STAT5b suppresses proliferation, induces G1 cell cycle arrest and reduces tumor cell invasion in human glioblastoma multiforme cells. Cancer Letters 2008; 273: 164-171（IF:4.258）

25. Zhang H, Gao GD, Yao QH, Gao X：Focal cortex disconnection for the treatment of intractable epilepsy. Epilepsia 2005; 46(suppl.6):323（IF:3.227）

      Zhang H, Gao GD, Liang QC, Zhao YQ, Wang QF, Wang XL：Analysis of complications of radiofrequency pallidot

      omy. Neurosurgery 2003; 52(1):89-101(IF:2.5)

 

Awards and honors

Five projects have been presided over by Zhang Hua:

1. Jan.1, 2015-Dec.31,2018 Study of the role of NAD synthesized NMNAT3 regulating mitochondrial oxidative stress in the mechanism of epilepsy  (Surface Project of National Natural Science Foundation of China, No.81471322)

2. Jan.1,2013-Dec.31,2016 Study of the role of lactate transporter in regulating glutamate transporter in the pathogenesis of epilepsy  (Surface Project of National Natural Science Foundation of China, No.81271433)

3. Jan.1,2008-Dec.31,2011 Study of desynchronization effect of early warning feedback electrical stimulation on initial synchronous discharge of epilepsy (Surface Project of National Natural Science Foundation of China, No.30772221)

4. Jan.1,2021-Dec.31,2022 Application of optogenetics technique-based treatment of drug-refractory temporal lobe epilepsy  (Key Research and Development Project of Shaanxi Province, No.2021SF-083)

5. Jan.1,2013-Dec.31,2014 Role of lactic acid in regulating aminobutyric acid receptor in the pathogenesis of epilepsy  (Key Scientific and Technological Project of Shaanxi Province, No.2012D3)

 

Zhang Hua has obtained the following awards in recent years: 1 second prize of State Technological Invention Award, 1 first prize and 1 second prize of Medical Achievement Award of PLA, 1 second prize of Scientific and Technological Award of Shaanxi Province, Honorary title of National Outstanding Youth Workers, and Young and Middle-aged Neurosurgery Physician Award of Wang Zhong Cheng Medical Foundation.