Recently, the team of Professor Mu Jianjun from the First Affiliated Hospital of Xi 'an Jiaotong University (XJTU) cooperated with the team led by Lu Yao, an invited researcher from the Third Xiangya Hospital of Central South University, and published the latest original research results in an article entitled "Early life body mass index trajectories and albuminuria in midlife: a 30-year prospective cohort study" in eClinicalMedicine, a journal of The Lancet. The findings in this study demonstrated that higher body mass index (BMI) trajectories early in life are independently associated with higher urinary albumin-to-creatinine ratio (uACR) and an increased risk of albuminuria in middle age, especially in males, suggesting that identifying long-term BMI trajectories from an early age may assist in predicting the risk of renal diseases and cardiovascular disease later in life.
In this study, group-based trajectory modeling (GBTM) was used to identify the BMI trajectories over 30 years since 1987 based on "Hanzhong Adolescent Hypertension Study Cohort", representing the weight changes in Chinese population over 30 years since China's reform and opening up. In this study, BMI trajectories tend to gradually increase from childhood, adolescence, adulthood to middle age, and are significantly associated with higher uACR and an increased risk of albuminuria later in life, offering potential strategies for early prevention and treatment of cardiovascular and renal diseases.
Two research teams collectively completed this original study covering from cohort recruitment, study design, case follow-up, basic experiment and statistical analysis. Meantime, Professor Robert Safirstein and Assistant Professor John Chang from Yale University delivered professional guidance and assistance. This work was a Key Project of Clinical Research Center of our hospital (XJTU1AF-CRF-2019-004). In addition, this work was also supported by Major Chronic Non-communicable Disease Prevention and Control Research Key Project of the Ministry of Science and Technology of China, National Natural Science Foundation of China, Key Research and Development Program of Shaanxi Province, Outstanding Youth Project of Hunan Province, Natural Science Foundation of Shaanxi Province and Institutional Foundation of the First Affiliated Hospital of XJTU, etc.
The First Affiliated Hospital of XJTU is the first and corresponding affiliation. Wang Yang, a doctoral student from Professor Mu Jianjun's team and Li Fei, a graduate student from the Third Xiangya Hospital of Central South University, are the co-first authors. Professor Mu Jianjun and invited researcher Lu Yao are the co-corresponding authors of this article.
Article link:https://www.thelancet.com/journals/eclinm/article/PIIS2589-5370(22)00150-X/fulltext
