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The first ex vivo heart perfusion system in Northwest China is successfully developed

Updated: Nov 16, 2020
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Edited by: Liu Huiting
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Recently, the ECMO team from the First Affiliated Hospital of Xi 'an Jiaotong University (XJTU) collaborated with School of Mechanical Engineering of XJTU and the National and Local Joint Engineering Center of Precision Surgery and Regenerative Medicine to successfully design and construct the first ex vivo heart perfusion system in Northwest China, making contribution to the innovation in the field of heart transplantation in China.

The protection of transplanted organs has always been a hot spot in the field of organ transplantation. Traditionally, due to technical limitations, the ex vivo organs have to be stored with organ preservation solution and cryopreserved. However, along with the expansion of organ transplantation cases and the increasing quantity of DCD marginal donors, certain drawbacks of conventional methods of organ protection and preservation gradually emerge, especially that the preservation time of ex vivo heart cannot exceed 6 h, which significantly restricts the development of heart transplantation. Mechanical perfusion at room temperature (the same principle as ECMO) is to deliver blood perfusion to the transplanted organs at room temperature in an ex vivo environment, maintain normal physiological state of the organs, continue the coronary circulation of theex vivo donor heart, and place organs in a warm and beating environment resembling the physiological state of human body. Prior to transplantation, the heart ischemia time should be minimized as possible, thereby making it possible to transport the donor heart from a long distance and resolve the issue of the donor heart damage or failure caused by organ ischemia during the process of long-distance transportation. Lately, academic articles published in Nature, Lancet and other journals have confirmed that mechanical perfusion at room temperature can effectively repair the ex vivo organs and prolong the preservation time of ex vivo organs. A large number of animal experiments and few clinical trials have verified the reliability of this equipment. According to our knowledge, Organ Care System (the United States) is the only commercial mechanical heart perfusion at room temperature abroad. In China, only the teams from Beijing and Wuhan are engaged in the research and development of such equipment.

Under the financial support of Key Research and Development Project of Shaanxi Province (Development of organ oxygenation and perfusion equipment at room temperature based on phosphate choline coating technology, 2020ZDLSF04-11), ECMO team from the First Affiliated Hospital of XJTU, National and Local Joint Engineering Center of Precision Surgery and Regenerative Medicineand School of Mechanical Engineering of XJTU have carried out a series of studies. At present, the core components of heart mechanical perfusion equipment at room temperature have been initially completed, which has been proven to be viable inex vivocanine heart. The outfit design of the perfusion equipment is being conducted. The successful research and development of this heart perfusion system will enhance the utilization efficiency of donor hearts, prolong the survival time ofex vivoheart, reduce the risk of heart transplantation and improve the long-term survival rate of heart transplantation.

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