On January 11, 2023, the kick-off meeting of "Clinical study of establishment and efficiency evaluation of CapriniPRS-15 risk prediction model for deep venous thromboembolism in surgical departments" initiated by Professor Lu Shaoying from Department of Vascular Surgery of the First Affiliated Hospital of Xi’an Jiaotong University (XJTU) was successfully held. It is a multi-center and multi-disciplinary clinical trial, led by Department of Vascular Surgery of our hospital and cooperated with multiple surgical departments from 14 large-scale tertiary hospitals in northwest China including the Second Affiliated Hospital of XJTU, Shaanxi Provincial People's Hospital, General Hospital of Ningxia Medical University, Lanzhou University Second Hospital and the First Affiliated Hospital of Xinjiang Medical University,etc.
Effective prediction of venous thromboembolism (VTE) is the fundament of clinical prevention and treatment. At present, Caprini risk prediction score is the most effective scoring standard for VTE, which has been widely recognized by surgical departments and recommended by multiple domestic and international guidelines. Studies have shown that genetic risk accounts for 40%-60% of the overall risk of VTE. However, the frequency of coagulation factor V Leiden and prothrombin G20210A mutations included in Caprini scoring standard is almost zero in Chinese population, suggesting that Caprini score is not suitable for Chinese population. Therefore, establishing a risk assessment model suitable for Chinese population is the key to prevent VTE.
The first kick-off meeting of this pilot clinical research was held in our hospital, chaired by Professor Yao Yingmin. Professor Lu Shaoying reported the background, preliminary work basis and highlights of subsequent multi-disciplinary cooperation. Professor Yao Yingmin stressed that they will fully support this project, strengthen cooperation with Department of Vascular Surgery and work together for the construction of National Medical Center. During the meeting, potential problems in promoting clinical application were also discussed.
Professor Lu Shaoying highlighted that it is extremely meaningful to explore the genetic risk of VTE in Chinese population and establish the first CapriniPRS-15 risk prediction scoring standard for VTE in China. Currently, although the project has proceeded into the pilot clinical trial stage, it cannot be achieved without tremendous efforts. During the preliminary stage, they’ll spare no effort to lay solid foundation for successful cooperation among more departments and hospitals.
